Recurrent meningitis in a family with C3 deficiency.

INDIAN PEDIATRICS 269 VOLUME 43MARCH 17, 2006 A 3-year-old girl presented to us in November 1998 with fever, headache and altered sensorium of two days duration. She was sick, irritable, drowsy and had neck rigidity. Blood counts showed leucocytosis. CSF came under high pressure and was turbid. It had 550 cells per mm3 with 65% polymorphs and 35% lymphocytes. CSF proteins were 2 g/dL and glucose was 0.7 mg/dL. Gram stain showed gram positive cocci and CSF culture grew Streptococcus pneumoniae. She was treated with IV Ceftriaxone and made a complete and uneventful recovery. She presented again after 31⁄2 with another episode of fever, lethargy and vomiting. CSF and blood culture again revealed streptococcus pneumoniae. She was again treated with IV Ceftriaxone and made complete recovery. She had a past history of two episodes of otitis media and one episode of Escherichia coli urinary tract infection.